Songenova
Membraneless perfusion. Intelligent automation. Boundless scale-up.
With AI accelerating drug discovery, new cell and gene therapies are being developed faster than we can manufacture them. Songenova is building bioreactors to close that gap before it becomes the same bottleneck that stalled antibody manufacturing.
TECHNOLOGY
The CentriFLEX Bioreactor
CENTRIFUGAL FLUIDIZED EXPANSION
Our technology retains cells by balancing centrifugal forces with opposing medium flow.
No membrane filters.
No fouling.
Performance highlights:
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Reach 100 million cells/mL in under 7 days.
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Grow cells at 95% of the maximum specific growth rate.
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Maintain expected cell phenotypes and functionality.
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Limit operator-interaction and prevent excess use of valuable culture medium with process-informed feeding controls.
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Save space with the 0.25 cubic meter footprint.
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Easily transition between runs with single-use tubing kits and system-integrated HEPA filters and UV-C sterilization switches.
TEAM
We believe no incredible feat is accomplished alone. Every individual draws inspiration, motivation, and wisdom from the people around them.
Kitana Kaiphanliam, PhD
Co-Founder & CEO
Eric Barrow
Co-Founder & VP of Prototype Development
Bernard Van Wie, PhD
Engineering Advisor
William Davis, PhD
Microbiology Advisor
PUBLICATION HIGHLIGHTS
Human T lymphoblastic leukemia cell line expansion (NEW! 2026-06-15)
Fraser-Hevlin B, Kaiphanliam KM, Moore Z, Davis WC, and Van Wie BJ (2026). A centrifugal bioreactor for immunotherapy: modeling and optimization of the growth of human T lymphoblastic leukemia cells. Biotechnology and Bioprocess Engineering. https://doi.org/10.1007/s12257-026-00298-y
Bovine CD8 cytotoxic T cell line expansion
Kaiphanliam KM, Fraser-Hevlin B, Barrow ES, Davis WC, and Van Wie BJ (2023). Development of a centrifugal bioreactor for rapid expansion of CD8 cytotoxic T cells for use in cancer immunotherapy. Biotechnology Progress, 39(6):e3388. https://aiche.onlinelibrary.wiley.com/doi/10.1002/btpr.3388
Digital twin development with cybersecurity applications
Fraser-Hevlin B, Schuler AW, Gozen AB, and Van Wie BJ (2024). Using digital twins to protect biomanufacturing from cyberattacks, Military Cyber Affairs, 7(1), Article 7. https://digitalcommons.usf.edu/mca/vol7/iss1/7/
Washington State University
National I-Corps led by Interior Northeast Hub
at Cornell University (award no. 2403974)
Early Grant for Exploratory Research
National Science Foundation
TRACTION
Founders' Forum
Women in Bio
San Diego
Washington Research Foundation
